-Spouse
Carin van der Donk (22 March 1997 - 2003) (divorced) 2 children
Carin van der Donk (22 March 1997 - 2003) (divorced) 2 children
Greta Scacchi (1991 - 1993) (divorced) 1 child
-Vincent's sister, Actress, Producer, Director, Writer Elizabeth D'Onofrio, teaches acting in Asheville, North Carolina.
-son of actor Gene D'Onofrio.
-Daughter: Leila George D'Onofrio, born March 20, 1992. Her mother is actress Greta Scacchi.
-Son: Elias Gene D'Onofrio, born in January 2000. His mother is Carin van der Donk.
-Son: Elias Gene D'Onofrio, born in January 2000. His mother is Carin van der Donk.
-Son: Luca D'Onofrio, born February 14, 2008. His mother is Carin van der Donk.
-Divorced wife Carin van der Donk in 2003. The couple reconciled in 2007 and had a son, Luca, in 2008. They have not remarried.
-Uncle of actor Hakan D'Onofrio.
